health

February 27, 2026

Christina Applegate reveals she is largely confined to bed due to multiple sclerosis

Actor, who was diagnosed with MS in 2021, says taking her 15-year-old daughter to school has become her ‘favourite thing to do’

Christina Applegate reveals she is largely confined to bed due to multiple sclerosis

TL;DR

  • Christina Applegate is largely confined to bed five years after her multiple sclerosis diagnosis.
  • She finds it difficult to move due to pain but still makes time to take her daughter to school.
  • Applegate's memoir, "You With the Sad Eyes," discusses her childhood and life experiences.
  • MS is an autoimmune disease affecting the nerve fiber sheath, impacting communication between the brain and body.
  • The disease predominantly affects women, lowers life expectancy, and can lead to challenges with walking and movement.
  • Applegate also underwent a bilateral mastectomy in 2008 after a breast cancer diagnosis.
  • She now focuses on voice acting and co-hosts a podcast about MS called MeSsy with Jamie-Lynn Sigler.

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