The Timing Hypothesis That Redeemed HRT
This is what most women don’t know about hormone replacement therapy (HRT): Timing matters more than age. The key isn’t whether you’re 45 or 55 when you start HRT; it’s when you start relative to your menopause transition.

TL;DR
- Timing of hormone replacement therapy (HRT) is more important than age for health benefits.
- The 'therapeutic window' or 'timing hypothesis' emphasizes starting HRT relative to menopause.
- Past confusion surrounding HRT stemmed from incorrect timing and patient selection.