health
What causes runner’s high
A few lucky runners can look forward to ‘an orchestra of neurochemical changes’ when they lace up their trainers. Why do the rest of us just get sweaty? And do other forms of exercise have the same effect?

TL;DR
- Runner's high is caused by a combination of neurochemical changes, with endocannabinoids (eCBs) playing a central role, rather than just endorphins.
- Endocannabinoids are internally produced compounds similar to those in cannabis, involved in pain management, stress reduction, and euphoria.
- Moderate to vigorous sustained aerobic exercise reliably triggers the runner's high, with eCB levels increasing during and after the activity.
- Other neurochemicals like dopamine and norepinephrine also contribute to mood enhancement, motivation, and focus during exercise.
- The flow state, characterized by complete immersion in an activity, is distinct from but often associated with the runner's high.
- Factors influencing the likelihood of experiencing runner's high include individual brain chemistry, training methods, and sustained moderate-to-hard aerobic effort.
- While the runner's high has been documented in other activities like cycling and rowing, sustained moderate-intensity efforts are key.
- Some individuals may not experience the runner's high due to enzymes clearing endocannabinoids too quickly.