health
Genetics may help explain why results from weight-loss jabs vary, say scientists
Data on almost 28,000 patients suggests understanding gene variations could improve treatments for obesity
TL;DR
- Variations in two genes involved in gut hormone pathways may explain differing results and side effects from weight-loss jabs (GLP1 medicines).
- A study of nearly 28,000 patients found a specific GLP1 receptor variant (rs10305420) associated with slightly more weight loss.
- Another variant (rs1800437) was linked to nausea and vomiting with tirzepatide but not weight loss amount.
- While genetics plays a role, its overall impact on weight loss is modest, with factors like sex, drug type, dose, and duration being more significant.
- The findings suggest potential for future precision approaches in obesity treatment, but current evidence is insufficient to guide routine clinical decisions based on genetics alone.