The Timing Hypothesis That Redeemed HRT
This is what most women don’t know about hormone replacement therapy (HRT): Timing matters more than age. The key isn’t whether you’re 45 or 55 when you start HRT; it’s when you start relative to your menopause transition.

TL;DR
- Timing matters more than age when starting hormone replacement therapy (HRT).
- The "therapeutic window" or "timing hypothesis" is central to the modern HRT controversy.
- Starting HRT at the correct time relative to menopause is crucial for its benefits.
- Incorrect HRT administration in the past led to decades of confusion.